Phomopsidin
WebSep 19, 2024 · It has been reported that the origin of carbons in phomopsidin ( 3) was built by nine acetates and three methyl groups from l -methionine by feeding experiment with 13 C-labeled precursors [25]. A similar biogenesis has also been proposed for carneic acids A and B [27] and lovastatin [28]. WebAbstract The absolute configuration of phomopsidin, a marine-derived fungal metabolite from Phomopsis sp. isolated at Pohnpei, was determined by the exciton chirality method as 6S, 7S, 8S, 11S, 12R, and 15R. The biosynthetic study using 13C-labeled precursors revealed the origin of all carbon atoms in phomopsidin, which was built by nine acetates and three …
Phomopsidin
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WebNov 21, 2024 · Metabolite profiling of this crude extract tentatively revealed the presence of the following secondary metabolites: 1,8-dihydroxynaphthalene (1), anserinone B (2), phelligridin B (3), metacytofilin (4), phomopsidin (5) and vermixocin A (6). Compounds 2 and 3 have been shown to be cytotoxic in literature. WebJun 29, 2004 · Read "First Total Synthesis of Antimitotic Compound, (+)‐Phomopsidin., ChemInform" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
WebThey were isolated as major constituents of the stromata of Hypoxylon carneum, a species that had shown a highly specific secondary metabolite profile in a survey of xylariaceous ascomycetes based on HPLC profiling. Their chemical structures were elucidated by a combination of spectroscopic methods and by preparation of derivatives. WebPhomopsidin C21H30O3 CID 10381991 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, …
WebThey appear to be species-specific marker molecules in H. carneum from different geographic regions, but do not constitute major metabolites of more than 100 species of … WebHis research there focused on the use of the Diels-Alder reaction and intramolecular rearrangements (specifically lactonic Ireland-Claisen rearrangements) to rapidly synthesize the marine natural products Phomopsidin and Aspermytin A. He is a natural product/total synthesis organic chemist at heart.
WebJun 1, 2024 · Phomopsidin, a known inhibitor of beta-tubulin that targets the eukaryotic cytoskeleton, inhibited the pathogen, but also showed mild cytotoxic effects.
WebPhomopsin A C36H45ClN6O12 CID 6438581 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities ... flutter icon as imageproviderWebDec 5, 2012 · The Journal of Antibiotics - Identification of a new phomoxanthone antibiotic from Phomopsis longicolla and its antimicrobial correlation with other metabolites during fermentation flutter icon badgeWebApr 24, 2024 · During a survey of xylarialean fungi in Northern Iran, several specimens that showed affinities to the Hypoxylon rubiginosum complex were collected and cultured. A comparison of their morphological characters, combined with a chemotaxonomic study based on high performance liquid chromatography, coupled with diode array detection … greenham common peace gardenflutter icon button change colorWebOn the other hand, phomopsidin was not detected in other related, but apparently rare species like H. texense, H. crocopeplum and H. carneum. Only the two latter species, however, were represented in our study by cultures that were isolated from stromata growing on Fraxinus wood. In addition, our results need to be further validated because … greenham common policeWebAbstract. (Equation presented) The first total synthesis of (+)-phomopsidin has been achieved via a diastereoselective transannular Diels-Alder (TADA) reaction. Key steps in … greenham common protest songsWebDec 5, 2012 · The Journal of Antibiotics - Identification of a new phomoxanthone antibiotic from Phomopsis longicolla and its antimicrobial correlation with other metabolites during … flutter iconbutton background color