Irf3 transcription factor
WebPreviously, it was shown that IRF3 is a downstream transcription factor that regulates the expression of IFNβ induced by TRIF-dependent TLRs 28, 29. ... 22, via the inhibition of NLRP1 and NLRP3 inflammasome, or via induction of IL-10 who then through activation of STAT3 transcription factor reduced the abundance of pro-IL-1a and pro-IL-1β. WebNov 1, 2012 · IRF3 and IRF7 have multiple sites that—upon viral infection—are substrates for phosphorylation by the serine/threonine kinases TANK-binding kinase 1 (TBK1) and IκB …
Irf3 transcription factor
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WebThe infection of mammalian cells by viruses and innate immune responses to infection are spatiotemporally organized processes. Cytosolic RNA sensors trigger nuclear translocation of the transcription factor interferon regulatory factor 3 (IRF3) and consequent induction of host immune responses to RNA viruses. WebMar 9, 2024 · IRF3 is a major transcriptional regulator of adipose inflammation and is involved in maintaining systemic glucose and energy homeostasis Findings indicate that STING-TBK1-IRF3 pathway mediates a crosstalk between ER stress and apoptosis during M. bovis infection, which can effectively control intracellular bacteria.
WebIRF3 → Interferon regulatory factor 3 (IRF-3) Gene name : IRF3 Family name : IRF Entry whose protein (s) existence is based on evidence at protein level. Show evidences Annotations in this section apply to all the isoforms if not specified otherwise. OVERVIEW WebIRF3 is a transcription factor that controls multiple IFN-inducing pathways, including the TLR3 pathway, which can be triggered by dsRNA, and the pathways triggered by other …
WebHowever, the mechanisms by which IRF3 causes ALD remain obscure.IRF3 is a constitutively expressed transcription factor that resides in the cytoplasm and dimerizes … WebJun 5, 2024 · Interferon regulatory factor 3 (IRF3) has been implicated in adipogenesis. However, the role of IRF3 in obesity and obesity-associated disorders remains unclear. Here, we show that IRF3...
WebIRF3 is a transcription factor which is a major regulator of the type I interferon (IFN) antiviral response after recognition of viral DNA or RNA by intracellular foreign nucleic acid sensors, such as Toll-like receptors (TLRs), retinoic acid-inducible gene I (RIG-I), and cyclic GMP-AMP synthase (cGAS) (reviewed in [10]). IRF3 activa-
WebTranscription factors IRF3 activates toll-like receptor-independent type I IFN production, which are very important in inducing IFN-γ production. 32 IFN-α/β is one of the most … income tax on 75 000 australiaWebIRF3 is a transcription factor that controls multiple IFN-inducing pathways, including the TLR3 pathway, which can be triggered by dsRNA, and the pathways triggered by other … income tax on 60000 ontarioWebMar 29, 2024 · IRF3 is activated by phosphorylation (by kinases TBK1 and IKKε), promoting dimerization, nuclear translocation, association with the co-activator CREB-binding protein … income tax on 75000 australiaWebSince STAT2 inhibits the transcription of IRF3-dependent, but not NF-kB–dependent genes, STAT2 may impair the ability of TBK1 to phosphorylate IRF3 by disrupting the IRF3–STING interaction. On the other hand, STAT2 has a strong nuclear export signal when Y690 is not phosphorylated ( 50 ). inch size ball bearing catalogueWebNov 20, 2024 · Interferon Regulatory Factors (IRFs) are a family of transcription factors that signal downstream of multiple pathways, including Toll-like receptor (TLR), retinoic acid-inducible gene I (RIG-I), melanoma differentiation associated gene 5 (MDA5), and B cell receptor (BCR) signaling pathways to regulate gene expression involved in both innate … inch simpleWebThe downstream signaling pathways from PRR activation phosphorylate ubiquitously expressed IRFs (IRF1, IRF3, and IRF7) through IRF kinases, such as TANK-binding kinase 1 … inch size flame resistant tubeWebIRF3 Transcription Factor Assay Kit (Colorimetric) (ab207210) is a high throughput assay to quantify IRF3 activation in nuclear extracts. This assay combines a quick ELISA format … inch sing