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High Mobility Group Box 1 Release by Cholangiocytes Governs ...

WebApr 1, 2005 · High-mobility group box 1 protein is a multifunctional protein originally identifi ed as a nuclear transcription modifi er that binds with receptors for advanced glycation end products (RAGE) as well as Toll-like receptor 2 (TLR2) and TLR4 leads to nuclear release. High-mobility group box 1 (HMGB1) protein: friend and foe. L. Ulloa, D. Messmer WebHMGB1 = high-mobility group box 1 protein; HMGB1 Ag = HMGB1 antigen. Recently, we showed that depletion of BM-DM by clodrolip exposure blocks surgery-induced neuroinflammation and cognitive decline. 15 To determine whether HMGB1-induced cognitive decline requires the participation of BM-DM, mice were exposed to clodrolip or … diamond art cowboys

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WebMar 1, 2006 · High mobility group box 1 (HMGB1), originally described as a DNA-binding protein, can also be released extracellularly and functions as a late mediator of inflammatory responses. Although recent reports have indicated that the receptor for advanced glycation end products (RAGE) as well as Toll-like receptor (TLR)2 and TLR4 are … High mobility group box 1 protein, also known as high-mobility group protein 1 (HMG-1) and amphoterin, is a protein that in humans is encoded by the HMGB1 gene. HMG-1 belongs to the high mobility group and contains a HMG-box domain. See more Like the histones, HMGB1 is among the most important chromatin proteins. In the nucleus HMGB1 interacts with nucleosomes, transcription factors, and histones. This nuclear protein organizes the DNA and … See more HMGB1 is secreted by immune cells (like macrophages, monocytes and dendritic cells) through leaderless secretory pathway. … See more HMGB1 has been proposed as a target for cancer therapy, as a vector for reducing inflammation from SARS-CoV-2 infection. and as a biomarker for post-COVID-19 condition. The neurodegenerative disease spinocerebellar ataxia type 1 See more HMGB1 has to interact with p53. HMGB1 is a nuclear protein that binds to DNA and acts as an architectural chromatin-binding … See more • Thomas JO, Travers AA (March 2001). "HMG1 and 2, and related 'architectural' DNA-binding proteins". Trends in Biochemical … See more • HMGB1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) • Pancreatic Cancer Research and HMGB1 Signaling Pathway See more WebJul 3, 2008 · Objective— High mobility group box 1 protein (HMGB1) was identified as a mediator of endotoxin lethality. We previously reported that thrombomodulin (TM), an endothelial thrombin-binding protein, bound to HMGB1, thereby protecting mice from lethal endotoxemia. However, the fate of HMGB1 bound to TM remains to be elucidated. diamond art cow pictures