Hepatic asialoglycoprotein receptor
Web20 jan. 2000 · The human asialoglycoprotein receptor (ASGPR), also called hepatic lectin, is an integral membrane protein and is responsible for the clearance of desialylated, galactose-terminal glycoproteins from the circulation by receptor-mediated endocytosis. WebMost notable of these is the asialoglycoprotein receptor (ASGPR1), a liver-specific protein that is highly produced in well-differentiated hepatocytes. Its utility as a definitive marker of hepatocyte identity is well established, and it has been used to isolate stem cell-derived hepatocytes. 51 As shown in Figure 4 , ASGPR1 is expressed on the cell surface by …
Hepatic asialoglycoprotein receptor
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WebThe hepatic carbohydrate-recognizing asialoglycoprotein receptor (ASGR1) mediates the endocytosis/lysosomal degradation of desialylated glycoproteins following … WebHepatic asialoglycoprotein receptor-mediated binding of human polymeric immunoglobulin A Authors C K Daniels 1 , D L Schmucker , A L Jones Affiliation 1 Cell …
Web24 jan. 2012 · The asialoglycoprotein receptor (ASGPR) is a high-capacity galactose-binding receptor expressed on hepatocytes that binds its native substrates with low affinity. More potent ligands are of interest for hepatic delivery of therapeutic agents. Web19 nov. 2010 · The Hepatic Asialoglycoprotein Receptor Regulates Platelet Homeostasis Renata Grozovsky, Renata Grozovsky * 1 BWH and HMS, Boston, MA, USA, Search for other works by this author on: This Site. PubMed. Google Scholar. Gerard Jansen, MD, PhD, MSC, Gerard ...
Web18 okt. 2024 · Human genetic studies combined with biotechnological advances have guided and accelerated the development of PCSK9-targeting therapies. In this Clinical Outlook, we highlight present and future ... WebThe asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the …
Web5 mei 2016 · ASGR1 has long been recognized as a hepatic surface marker (Ashwell and Morell, 1974; Schwartz et al., ... Detection of circulating tumor cells in hepatocellular carcinoma using antibodies against asialoglycoprotein receptor, carbamoyl phosphate synthetase 1 and pan-cytokeratin. PLoS ONE 9, e96185 10.1371/journal.pone.0096185 ...
Web2 aug. 2012 · The asialoglycoprotein receptor (ASGPR) is a hepatic receptor that mediates removal of potentially hazardous glycoconjugates from blood in health and disease. The receptor comprises two proteins, asialoglycoprotein receptor 1 and 2 (ASGR1 and ASGR2), encoded by the genes ASGR1 and ASGR2. understanding texas holdemWeb22 nov. 2011 · A well-established target for specific drug delivery to hepatocytes is the hepatic C-type lectin asialoglycoprotein receptor (ASGPR). ASGPR is expressed at high levels on hepatocytes (approximately 500,000 copies/cell) and plays an important role in the clearance of desialylated glycoproteins from serum via receptor mediated endocytosis … understanding tableauThe asialoglycoprotein receptors (ASGPR) are lectins which bind asialoglycoprotein and glycoproteins from which a sialic acid has been removed to expose galactose residues. The receptors, which are integral membrane proteins and are located on mammalian hepatocytes (liver cells), … Meer weergeven The asialoglycoprotein receptor was first characterized in 1968 by Morell et al. and was the first mammalian lectin identified. The researchers transferred radioactively-labeled ceruloplasmin that had undergone a reaction … Meer weergeven • Asialoglycoprotein+receptor at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Meer weergeven Asialoglycoprotein receptors function to catabolize galactosyl and N-acetylgalactosaminyl-containing substrates. More specifically, in most mammals, … Meer weergeven The human asialoglycoprotein receptors composed of two units, H1 and H2. Each of these units have their N-terminus within the cytoplasm of a liver cell, and a carbohydrate recognition domain (CRD) on the extracellular side. The CRD functions to … Meer weergeven understanding te tiriti o waitangiWebIntroduction. SARS-CoV-2 is the virus responsible for the COVID-19 pandemic and its damaging effects on both health and economics worldwide. Transmission and pathology of the virus appears to be mediated through the respiratory system via interaction of the viral spike protein with the ACE-2 receptor 1–3 differentially presented on various cells within … understanding the 2022 w-4 formWeb29 mrt. 2024 · In this work, we report the evaluation of lactosylated graphene oxide (GO-AL) as a potential drug carrier targeted at an asialoglycoprotein receptor (ASGPR) from hepatic cancer cells. Structural-modification, safety evaluation, and functional analysis of GO-AL were performed. understanding the apple ii by jim satherWeb25 dec. 2001 · The role of the asialoglycoprotein receptor in clearance was studied by preinjection (at 1 min before injection of the radiolabel) of 50 mg·kg −1 body weight of asialo-fetuin (a blocker of the asialoglycoprotein receptor). Injection of α3-galactosylated α 1 -AGP was done in duplicate, that of asialo-α 1 -AGP in triplicate. understanding taxes buying and sellingWeb20 apr. 2001 · The asialoglycoprotein receptor (ASGPR) 1 was originally identified by Ashwell and Morell as a hepatic receptor that mediates the rapid clearance of serum glycoproteins containing terminal galactose residues … understanding the bathroom controversy