WebTakahashi et al. (1994) identified an apparent polymorphism of the CNTF gene. An acceptor splice site mutation caused aberrant mRNA splicing and abolished expression of CNTF protein. The specific change was a G-to-A transition at position -6 of the acceptor splice site leading to insertion of 4 additional ribonucleotides at the beginning of the next exon. WebFurther evidence implies the importance of CNTF in MS by showing that CNTF and the CNTF receptor complex are strongly upregulated in the cerebral cortex of MS patients (Dutta et al., 2007). Consistent with this finding, CNTF mRNA is highly upregulated during demyelination and remyelination in the cuprizone-demyelinated mouse corpus callosum ...
Rat ciliary neurotrophic factor (CNTF): gene structure and
WebMay 21, 2013 · CNTF is repressed by ECM and specific αvβ5 integrin and neuronal Thy-1 ligand. A) C6 astroglioma cells grown for 4 h on laminin (LAM), fibronectin (FN1) and vitronectin (VTN) had lower levels of CNTF mRNA compared to poly-d-lysine control (Ctrl, set at 1.00) as quantified by qRT-PCR.Fibrinogen (FG), thrombospondin (TSP), and … dr ann davis highlands nc
Ciliary Neurotrophic Factor (CNTF) in Combination with Its Soluble ...
WebCNTF gene therapy was carried out using an AAV that targets RGCs (and some amacrine cells). AAV2-CNTF increased CNTF mRNA levels ∼30-fold above background and ∼20 … WebCiliary neurotrophic factor. Ciliary neurotrophic factor is a protein that in humans is encoded by the CNTF gene. [5] [6] [7] The protein encoded by this gene is a polypeptide hormone and neurotrophic factor whose actions have mainly been studied in the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain ... WebThe rat mRNA is encoded by a simple two-exon transcription unit. Sequence analysis of the region upstream of the transcription start-site did not reveal a typical TATA-box … dr anne aly minister