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WebDose levels should be spaced to produce a gradation of effects. (ii) The high dose level in rodents should elicit some signs of toxicity without causing excessive lethality; for non-rodents, there should be signs of toxicity but there should be no fatalities. (iii) The lowest dose level should not produce any evidence of toxicity. Web3. ACUTE, SUBCHRONIC, AND CHRONIC TOXICITY 3.1. SCOPE AND LIMITATIONS The acute, subchronic, and chronic toxicology of the chlorinated dioxins, dibenzofurans, biphenyls, and related compounds have been reviewed extensively in recent years. This chapter summarizes knowledge on the toxicology of tetrachlorodibenzo-p-dioxin (TCDD), … how did rayan fall in the well
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